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HepaticAspartate transaminaseASTand/or alanine transaminaseALTvalues exceeded twice the upper limit of normal in approximately 1to 2of 723 patients receiving ZOFRAN and cyclophosphamide-based chemotherapy in US clinical trialsThe increases were transient and did not appear to be related to dose or duration of therapyOn repeat exposuresimilar transient elevations in transaminase values occurred in some coursesbut symptomatic hepatic disease did not occurThe role of cancer chemotherapy in these biochemical changes is unclear.

Every effort has been made to ensure that the information provided by Cerner MultumIncMultumis accurateup-to-dateand completebut no guarantee is made to that effectDrug information contained herein may be time sensitiveMultum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriateunless specifically indicated otherwiseMultum’s drug information does not endorse drugsdiagnose patients or recommend therapyMultum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement toand not a substitute forthe expertiseskillknowledge and judgment of healthcare practitionersThe absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safeeffective or appropriate for any given patientMultum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum providesThe information contained herein is not intended to cover all possible usesdirectionsprecautionswarningsdrug interactionsallergic reactionsor adverse effectsIf you have questions about the drugs you are takingcheck with your doctornurse or pharmacist.

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