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HepaticAspartate transaminaseASTand/or alanine transaminaseALTvalues exceeded twice the upper limit of normal in approximately 1to 2of 723 patients receiving ZOFRAN and cyclophosphamide-based chemotherapy in US clinical trialsThe increases were transient and did not appear to be related to dose or duration of therapyOn repeat exposuresimilar transient elevations in transaminase values occurred in some coursesbut symptomatic hepatic disease did not occurThe role of cancer chemotherapy in these biochemical changes is unclear.
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ZOFRAN ODT orally disintegrating tablets are whiteroundand plano-convex tablets available in the following strengths:
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